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Aqueous extract from Chaga medicinal mushroom, Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.

Chaga medicinal mushroom, Inonotus obliquus, a popular prescription in traditional medicine in Europe and Asia, was used to reduce inflammation in the nasopharynx and to facilitate breathing. The aqueous extract from I. obliquus (AEIO) exhibited marked decrease in herpes simplex virus (HSV) infection (the 50% inhibitory concentration was 3.82 μg/mL in the plaque reduction assay and 12.29 μg/mL in the HSV-1/blue assay) as well as safety in Vero cells (the 50% cellular cytotoxicity was > 1 mg/mL, and selection index was > 80). Using a time course assay, effective stage analysis, and fusion inhibition assay, the mechanism of anti-HSV activity was found against the early stage of viral infection through inhibition of viral-induced membrane fusion. Therefore, AEIO could effectively prevent HSV-1 entry by acting on viral glycoproteins, leading to the prevention of membrane fusion, which is different from nucleoside analog antiherpetics.

http://www.ncbi.nlm.nih.gov/pubmed/23510282

Chaga has Anti-cancer and Gene-protective properties !!! 

The prevalence of polyphenolic composites in its granular core and pseudosclerotial plate (combined into sterile conk, so-called Chaga) indicates its clear antioxidant and gene-protective—i.e., anti-cancer, anti-microbial, and anti-hyperglycemic—activities. The glucan and triterpenoid profile of the mushroom allows the use of I. obliquus in some cases as a direct antitumor agent.  

http://media.wix.com/ugd/b65817_07d3adc6bd8949d39f226f18689745e6.pdf

Quote: Chaga grows in trees therefore cannot be patented. Cancer treatment (not cure) is over 1 TRILLION dollars business.

* Researchers from the world famous Vector Institute near Novosibirsk have found that Chaga mushrooms demonstrate low toxicity and a strong antiviral effect' against influenza, smallpox and HIV, the virus that causes AIDS, said a statement from the scientists at Vector.

http://siberiantimes.com/science/casestudy/news/siberian-16th-century-babushka-remedy-can-combat-hiv-and-other-viruses-claim

Quote: Reducing systemic inflammation can mitigate or help prevent a variety of health problems, leading to a healthier life – and presumably a longer one. Traditionally, Chaga has been used for a variety of purposes. Scientific investigation chaga’s use as an anti-allergy agent shows that in animals, the fungus has the ability to prevent anaphylactic shock – a serious and potentially fatal consequence of a severe allergy. In another study, administration of an extract of chaga reduced infection due to the Herpes simplex virus. In a cell study, Chaga showed potent activity against the hepatitis C virus. Whether this same activity will prove true in living humans remains to be seen, but if it does, then chaga will benefit thousands of people who often suffer for many years with this crippling disease.

http://www.foxnews.com/health/2013/05/29/chaga-potent-immune-enhancing-fungus

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